Structure of PDB 5maj Chain A

Receptor sequence
>5majA (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFESTSDNNKYWLVKNSWGEEWGMGGYVKM
AKDRRNHCGIASAASYPTV
3D structure
PDB5maj Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.
ChainA
Resolution1.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H163 N187
Catalytic site (residue number reindexed from 1) Q19 C25 H163 N186
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 7KH A G23 C25 N66 G67 G68 D162 G23 C25 N66 G67 G68 D162 PDBbind-CN: -logKd/Ki=7.46,Ki=35nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:5maj, PDBe:5maj, PDBj:5maj
PDBsum5maj
PubMed27992115
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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