Structure of PDB 5mag Chain A

Receptor sequence
>5magA (length=314) Species: 9606 (Homo sapiens) [Search protein sequence]
DYDELLKYYELHETIGTGGAKVKLACHILTGEMVAIKIMDKNTLDLPRIK
TEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLS
EEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCA
KSLAYAAPELIQGKLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKI
MRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPV
EWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLL
AKKARGKPVRLRLS
3D structure
PDB5mag The target landscape of clinical kinase drugs.
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D132 K134 E136 N137 D150 S171
Catalytic site (residue number reindexed from 1) D127 K129 E131 N132 D145 S152
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7KC A I17 G18 T19 V25 A38 C89 P90 G92 L139 I149 D150 I15 G16 T17 V22 A35 C84 P85 G87 L134 I144 D145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5mag, PDBe:5mag, PDBj:5mag
PDBsum5mag
PubMed29191878
UniProtQ14680|MELK_HUMAN Maternal embryonic leucine zipper kinase (Gene Name=MELK)

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