Structure of PDB 5m7t Chain A

Receptor sequence
>5m7tA (length=451) Species: 9606 (Homo sapiens) [Search protein sequence]
RFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWR
EMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKL
DQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGE
PETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKE
IPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLK
GVLTNPNCEFEANYVAIHTLATWYKSNMNDVLYSPQMALKLALTEWLQEF
GVPHQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREF
QWLRANSSVVSVKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTI
LYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSQEPWAFRGGLAGEFQRLLP
I
3D structure
PDB5m7t Structural and functional insight into human O-GlcNAcase.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDV A G67 K98 D175 Y219 F223 V254 W278 N280 D285 G9 K40 D117 Y161 F165 V196 W220 N222 D227 PDBbind-CN: -logKd/Ki=5.41,Ki=3.9uM
Gene Ontology
Molecular Function
GO:0004415 hyalurononglucosaminidase activity
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006493 protein O-linked glycosylation
GO:0006516 glycoprotein catabolic process
GO:0006517 protein deglycosylation
GO:0009100 glycoprotein metabolic process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5m7t, PDBe:5m7t, PDBj:5m7t
PDBsum5m7t
PubMed28346405
UniProtO60502|OGA_HUMAN Protein O-GlcNAcase (Gene Name=OGA)

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