Structure of PDB 5m6e Chain A

Receptor sequence
>5m6eA (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
MNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDK
VKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHS
LEECLV
3D structure
PDB5m6e Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
ChainA
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C300 C303 H320 C327 C53 C56 H73 C80
BS02 7HT A K297 G306 L307 T308 D309 W310 E314 Q319 W323 K50 G59 L60 T61 D62 W63 E67 Q72 W76
External links
PDB RCSB:5m6e, PDBe:5m6e, PDBj:5m6e
PDBsum5m6e
PubMed28492317
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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