Structure of PDB 5m5y Chain A

Receptor sequence
>5m5yA (length=1466) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLY
DLALGAFLRNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRA
SCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITLGDISSTLLN
ELKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLS
RGKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGFISTYILSTEV
KNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVLVVPPTRFRLP
SKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLRVIFSRLMNAFVTI
QNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKW
PGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRH
IKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDG
DEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVWL
TSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIFKPYPLWTGKQ
IITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGM
DDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQ
EILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMAL
SGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAGG
YVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGV
HVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPA
KYLGSVSENFQDKLESFLDKNSKGVNEKKFRALMQLKYMRSLINPGEAVG
IIASQSVGEPSTQMTLNTFNVTLGIPRLREIVMTASAAIKTPQMTLPIWN
DVSDEQADTFCKSISKVLLSEVIDKVIVTETTGARSYVIHMRFFDNNEYS
EEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQKRVEANNNMNKVQRDRQ
SAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSI
IRQIPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVA
AVLKTYGVEAARNTIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLA
FNRQGMETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIVVGKLN
NVGTGSFDVLAKVPNA
3D structure
PDB5m5y Molecular Structures of Transcribing RNA Polymerase I.
ChainA
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F248 E464 R475 Y1018 E1616 T1617 Q1620 F219 E384 R395 Y938 E1419 T1420 Q1423
BS02 ZN A C102 C233 C102 C204
BS03 ZN A C62 C65 H75 C62 C65 H75
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006361 transcription initiation at RNA polymerase I promoter
GO:0006362 transcription elongation by RNA polymerase I
GO:0006363 termination of RNA polymerase I transcription
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5m5y, PDBe:5m5y, PDBj:5m5y
PDBsum5m5y
PubMed27867008
UniProtP10964|RPA1_YEAST DNA-directed RNA polymerase I subunit RPA190 (Gene Name=RPA190)

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