Structure of PDB 5m5q Chain A

Receptor sequence
>5m5qA (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
SGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFK
YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPAQAA
AYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQ
EPFVAVVIDPTRKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVH
CKQYYALEVSYFKSSLDRK
3D structure
PDB5m5q Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H138 H140 D151 H126 H128 D139
BS02 7K1 A E76 V77 M78 W136 H138 H140 Y143 D151 T154 E73 V74 M75 W124 H126 H128 Y131 D139 T142 MOAD: ic50=0.09uM
PDBbind-CN: -logKd/Ki=7.05,IC50=0.09uM
BindingDB: IC50=60nM
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:5m5q, PDBe:5m5q, PDBj:5m5q
PDBsum5m5q
PubMed27981705
UniProtQ92905|CSN5_HUMAN COP9 signalosome complex subunit 5 (Gene Name=COPS5)

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