Structure of PDB 5m56 Chain A

Receptor sequence
>5m56A (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
PGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDGYQLVRKLGRGKY
SEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDT
VKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSK
GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP
ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG
TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL
LDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ
3D structure
PDB5m56 Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
ChainA
Resolution2.237 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) I153 H155 V158 L172 V191
Catalytic site (residue number reindexed from 1) I152 H154 V157 L171 V190
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7FC A L46 V67 K69 F114 E115 Y116 I117 M164 I175 D176 L45 V66 K68 F113 E114 Y115 I116 M163 I174 D175 PDBbind-CN: -logKd/Ki=7.89,Ki=13nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006302 double-strand break repair
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007283 spermatogenesis
GO:0016055 Wnt signaling pathway
GO:0016310 phosphorylation
GO:0021987 cerebral cortex development
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051726 regulation of cell cycle
GO:0097421 liver regeneration
GO:1901524 regulation of mitophagy
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1905818 regulation of chromosome separation
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005956 protein kinase CK2 complex
GO:0031519 PcG protein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:5m56, PDBe:5m56, PDBj:5m56
PDBsum5m56
PubMed28085026
UniProtP19784|CSK22_HUMAN Casein kinase II subunit alpha' (Gene Name=CSNK2A2)

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