Structure of PDB 5m55 Chain A

Receptor sequence
>5m55A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
SRAEDYEVLYTIGTRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEV
NLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQ
YLDEEFVLRVMTQLTLALKECHRRSLKPANVFLDGKQNVKLGDTPYYMSP
EQMNNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYR
YSDELNEIITRMLNLKDYHRPSVEEILENPLILEHHHHHH
3D structure
PDB5m55 Structure-guided design of purine-based probes for selective Nek2 inhibition.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K143 A145 N146 D159 T179
Catalytic site (residue number reindexed from 1) K127 A129 N130 D143 T144
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7GG A C22 E87 Y88 C89 G92 C16 E81 Y82 C83 G86 MOAD: ic50=0.24uM
PDBbind-CN: -logKd/Ki=6.62,IC50=0.24uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5m55, PDBe:5m55, PDBj:5m55
PDBsum5m55
PubMed27833088
UniProtP51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (Gene Name=NEK2)

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