Structure of PDB 5m51 Chain A

Receptor sequence
>5m51A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
SRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQML
VSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGT
KERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGK
QNVKLGDFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTA
FSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILEN
PLILEHHHHH
3D structure
PDB5m51 Structure-guided design of purine-based probes for selective Nek2 inhibition.
ChainA
Resolution1.899 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 A145 N146 D159 T179
Catalytic site (residue number reindexed from 1) D139 K141 A143 N144 D157 T161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NU6 A K37 E87 Y88 C89 F148 K35 E85 Y86 C87 F146 MOAD: ic50=19uM
PDBbind-CN: -logKd/Ki=4.72,IC50=19uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5m51, PDBe:5m51, PDBj:5m51
PDBsum5m51
PubMed27833088
UniProtP51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (Gene Name=NEK2)

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