Structure of PDB 5m3h Chain A

Receptor sequence

>5m3hA (length=699) Species: 11320 (Influenza A virus)

MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENDDDNAMLKHRFEIIEGQERNIAWTIVNSICNMTEN
SKPRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSF
DGEEMATDDEYILDEESRARIKTRLFVLRQELATALEEEFSYPPTFQRLA
NQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPRTI
RELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDTFW
GWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKWGL
GEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELTNS
NWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTALL
NSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVVNF
ISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTNGT
SKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRENDWP
IGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLLIQ
AFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSMG

3D structure

• PDB: 5m3h Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
• Chain: A
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	M472 H505 L506 R507 K567	M457 H490 L491 R492 K552
BS02	rna	A	R279 K281 H326 K328 W363 G366 E367 G368 Q369 A370 P371 Y388 K389 S390 P392 P393 R503 H505 V512 N514 R561 T562 N563 G564 K569	R264 K266 H311 K313 W348 G351 E352 G353 Q354 A355 P356 Y373 K374 S375 P377 P378 R488 H490 V497 N499 R546 T547 N548 G549 K554
BS03	peptide	A	L412 F440 A443 E444 Q447 K630 R633	L397 F425 A428 E429 Q432 K615 R618
BS04	peptide	A	A287 M288 K289 L290 T313 R449 M543 E544 I545 R546 T547	A272 M273 K274 L275 T298 R434 M528 E529 I530 R531 T532

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting

External links

• PDB: RCSB:5m3h, PDBe:5m3h, PDBj:5m3h
• PDBsum: 5m3h
• PubMed: 28002402
• UniProt: H6QM92