Structure of PDB 5m3a Chain A

Receptor sequence
>5m3aA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5m3a Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7E7 A W81 P82 L92 N140 I146 W40 P41 L51 N99 I105 PDBbind-CN: -logKd/Ki=5.70,IC50=2uM
BindingDB: IC50=2000nM
External links
PDB RCSB:5m3a, PDBe:5m3a, PDBj:5m3a
PDBsum5m3a
PubMed28910100
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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