Structure of PDB 5m1s Chain A

Receptor sequence
>5m1sA (length=927) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MSEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGL
VKFYGAGHGAGIKPIVGADFNVQCDLLGDELTHLTVLAANNTGYQNLTLL
ISKAYQRGYGAAGPIIDRDWLIELNEGLILLSGGRMGDVGRSLLRGNSAL
VDECVAFYEEHFPDRYFLELIRTGRPDEESYLHAAVELAEARGLPVVATN
DVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMRSEEEMCELF
ADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGL
EERLAFLFPDEEERLKRRPEYDERLETELQVINQMGFPGYFLIVMEFIQW
SKDNGVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMP
DFDVDFCMEKRDQVIEHVADMYGRDAVSQIITFGTMAAKAVIRDVGRVLG
HPYGFVDRISKLIPPDPGMTLAKAFEAEPQLPEIYEADEEVKALIDMARK
LEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQFDKSDVEYAG
LVKFDFLGLRTLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDML
QRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDN
FIDRKHGREEISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGY
TLGGADMLRRAMGKKKPEEMAKQRSVFAEGAEKNGINAELAMKIFDLVEK
FAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTEKVVGL
VDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAII
EARNKGGYFRELFDLCARTDTKKLNRRVLEKLIMSGAFDRLGPHRAALMN
SLGDALKAADQHAKAEAIGQLDLFGVL
3D structure
PDB5m1s Self-correcting mismatches during high-fidelity DNA replication.
ChainA
Resolution6.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A P452 Y453 R877 P452 Y453 R877
BS02 dna A T435 R443 R447 P467 K543 T435 R443 R447 P467 K543
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5m1s, PDBe:5m1s, PDBj:5m1s
PDBsum5m1s
PubMed28067916
UniProtP10443|DPO3A_ECOLI DNA polymerase III subunit alpha (Gene Name=dnaE)

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