Structure of PDB 5m05 Chain A

Receptor sequence
>5m05A (length=707) Species: 9031 (Gallus gallus) [Search protein sequence]
KLVWVPSEKHGFEAASIKEEKGDEVTVELQENGKKVTLSKDDIQKMNPPK
FSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPI
YSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAG
KTENTKKVIQYLAVVASSPYGELEKQLLQANPILEAFGNAKTVKNDNSSR
FGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGA
SEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLEAMTIMGFTEE
EQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTD
FTRSILTPRIKVGAAVVEKAQTKEQADFAIEALAKAKFERLFRWILTRVN
KALDKTKRQGASFLGILDIAGFEIFEINSFEQLCINYTNEKLQQLFNHTM
FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWF
PKATDTSFVEKLIQEQGNHAKFQKSDKTEFCILHYAGKVTYNASAWLTKN
MDPLNDNVTSLLNQSSDKFVADLWKDRTVGQLYKEQLTKLMTTLRNTNPN
FVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEF
RQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGV
LAHLEEE
3D structure
PDB5m05 Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
ChainA
Resolution2.675 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S179 G180 T184 N242 S245 S246 G468 E470
Catalytic site (residue number reindexed from 1) S147 G148 T152 N195 S198 S199 G421 E423
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 52E A A90 S117 G118 L119 M497 G709 V710 E712 G713 I714 C717 A58 S85 G86 L87 M450 G629 V630 E632 G633 I634 C637
BS02 MG A T184 S246 T152 S199
BS03 ADP A N125 P126 G180 G182 K183 T184 E185 N242 N93 P94 G148 G150 K151 T152 E153 N195
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:5m05, PDBe:5m05, PDBj:5m05
PDBsum5m05
PubMed27815532
UniProtP10587|MYH11_CHICK Myosin-11 (Gene Name=MYH11)

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