Structure of PDB 5lzq Chain A

Receptor sequence
>5lzqA (length=725) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
YVAALFFLIPLVALGFAAANFAAVVRKPEGTERMKEISSYIRSGADSFLA
HETKAIFKVAIVIAILLMIFTTWQTGVAFLLGAVMSASAGIVGMKMATRA
NVRVAEAARTTKKIGPALKVAYQGGSVMGLSVGGFALLGLVLVYLIFGKW
MGQVDNLNIYTNWLGINFVPFAMTVSGYALGCSIIAMFDRVGGGVYTKAA
DMAADLVGKTELNLPEDDPRNPATIADNVGDNVGDVAGLGADLLESFVGA
IVSSIILASYMFPIYVQKIGENLVHQVPKETIQALISYPIFFALVGLGCS
MLGILYVIVKKPSDNPQRELNISLWTSALLTVVLTAFLTYFYLKDLQGLD
VLGFRFGAISPWFSAIIGIFSGILIGFWAEYYTSYRYKPTQFLGKSSIEG
TGMVISNGLSLGMKSVFPPTLTLVLGILFADYFAGLYGVAIAALGMLSFV
ATSVSVDSYGPIADNAGGISEMCELDPEVRKITDHLDAVGNTTAAIGKGF
AIGSAIFAALSLFASYMFSQISPSDIGKPPSLVLLLNMLDARVIAGALLG
AAITYYFSGYLISAVTKAAMKMVDEIRRQAREIPGLLEGKAKPDYNRCIE
ITSDNALKQMGYPAFIAILTPLVTGFLLGAEFVGGVLIGTVLSGAMLAIL
TANSGGAWDNAKKYLEAGNLEGYGKGSEPHKALVIGDTVGDPLKDTVGPS
LDILIKIMSVVSVIAVSIFKHVHLF
3D structure
PDB5lzq Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism.
ChainA
Resolution3.495 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.3.1: Na(+)-exporting diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D202 D206 D201 D205
BS02 MG A D218 D465 D217 D464
BS03 MG A D202 D692 D201 D691
BS04 MG A D232 D465 D231 D464
BS05 MG A N492 D660 N491 D659
BS06 2PN A D202 D465 D201 D464
BS07 NA A D243 E246 S247 D703 I704 K707 D242 E245 S246 D702 I703 K706
BS08 2PN A L533 V534 L536 L532 V533 L535
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphate phosphatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0009678 diphosphate hydrolysis-driven proton transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0030955 potassium ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lzq, PDBe:5lzq, PDBj:5lzq
PDBsum5lzq
PubMed27922000
UniProtQ9S5X0|HPPA_THEMA K(+)-stimulated pyrophosphate-energized sodium pump (Gene Name=hppA)

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