Structure of PDB 5lyl Chain A

Receptor sequence
>5lylA (length=305) Species: 9823 (Sus scrofa) [Search protein sequence]
GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKP
GPNKPAIFMDCGIHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDF
YVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTG
ASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLSIHSYSQHIVY
PYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTLYLAPGGG
DDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYV
LGHLY
3D structure
PDB5lyl Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
ChainA
Resolution1.83 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H64 E67 R122 H192 E266
Enzyme Commision number 3.4.17.2: carboxypeptidase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H69 E72 H196 H64 E67 H192
BS02 ZN A E85 E291 E80 E287
BS03 T5F A H69 E72 R127 N144 R145 T164 H196 S197 Y198 S207 Y248 D255 E270 H64 E67 R122 N139 R140 T159 H192 S193 Y194 S203 Y244 D251 E266
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5lyl, PDBe:5lyl, PDBj:5lyl
PDBsum5lyl
PubMed27749053
UniProtP09955|CBPB1_PIG Carboxypeptidase B (Gene Name=CPB1)

[Back to BioLiP]