Structure of PDB 5lyh Chain A

Receptor sequence
>5lyhA (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
MKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQ
AKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSAVAYGKGTYFA
VNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNP
TDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB5lyh Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
ChainA
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7B8 A H1682 G1683 T1684 S1688 F1697 N1698 S1700 V1707 T1713 Y1714 F1715 A1716 Y1721 S1722 Y1727 H71 G72 T73 S77 F86 N87 S89 V91 T97 Y98 F99 A100 Y105 S106 Y111 MOAD: ic50=0.49uM
PDBbind-CN: -logKd/Ki=6.31,IC50=0.49uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5lyh, PDBe:5lyh, PDBj:5lyh
PDBsum5lyh
PubMed27918638
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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