Structure of PDB 5lxp Chain A

Receptor sequence
>5lxpA (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSY
QAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRYGKGTYFAVNA
NYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDL
YDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB5lxp Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7AG A H1682 G1683 Y1714 A1716 Y1721 S1722 T1726 Y1727 H72 G73 Y95 A97 Y102 S103 T107 Y108 MOAD: ic50=0.76uM
PDBbind-CN: -logKd/Ki=6.12,IC50=0.76uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5lxp, PDBe:5lxp, PDBj:5lxp
PDBsum5lxp
PubMed27918638
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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