Structure of PDB 5lx6 Chain A

Receptor sequence
>5lx6A (length=191) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYE
LYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGK
GVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLR
GPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHV
3D structure
PDB5lx6 Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 78P A H887 G888 C907 Y919 S927 Y932 H71 G72 C91 Y103 S111 Y116 MOAD: ic50=1900nM
PDBbind-CN: -logKd/Ki=5.72,IC50=1900nM
BindingDB: IC50=43800nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5lx6, PDBe:5lx6, PDBj:5lx6
PDBsum5lx6
PubMed28001384
UniProtQ53GL7|PAR10_HUMAN Protein mono-ADP-ribosyltransferase PARP10 (Gene Name=PARP10)

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