Structure of PDB 5lww Chain A

Receptor sequence

>5lwwA (length=550) Species: 5061 (Aspergillus niger)

PNTPWQGYDINTNYYETIPQTNVVREYWFDIVNTTAALDGVERPVLLVNG
QFPGPTIEANWGDTVKVHVTNRMENNGTAIHFHGIRQLYNNQMDGVAALT
QCPVPPNSSYTYVWRAEEYGSSWYHSHFSLQAWEGVFGGILIHGPSTAEY
DHDLGMVFLNDWSHQTVDEMYQSVLESQNPPHFQTGLINGSNIWVTADNQ
TVGRRFQTEFVPGQRYRLRLVNAAMHTHFRFSIDNHDLTVIASDFVPIVP
FTTNNVPIGMGQRYDIIVTANQAPDNYWIRAIPQSFCSDNANSDNIKGVL
HYEGAADNSDPTSTKWDYGDDIQCLDFSLDELVPWLALDADIGGAQMAES
DVDFTPFGDVPLYLWTMGGNALNISWKDPTLQQTFEDPDKMDWKASQGVI
EAAIPNKWTVLVVQTDLPVPHPIHLHGHDFYLLAQGFGQFNPQNVTLKTH
NPPRRDTALMTAATPENGGGGYMVIGFPADNPGVWLIHCHIGFHATEGFA
QQIVERQSEFNTFFSEDLLENTCDAWDEYAKVNPYGHQYRALAGPYESGI

3D structure

• PDB: 5lww Structure and function of Aspergillus niger laccase McoG
• Chain: A
• Resolution: 2.65 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H108 H110 H152 H154 H448 H451 H453 H515 C516 H517 I518 H521 F526
• Catalytic site (residue number reindexed from 1): H81 H83 H125 H127 H421 H424 H426 H488 C489 H490 I491 H494 F499
• Enzyme Commision number: 1.10.3.2: laccase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CU	A	H110 H152 H517	H83 H125 H490
BS02	CU	A	H154 H453 H515	H127 H426 H488
BS03	CU	A	H108 H451 H453	H81 H424 H426
BS04	CU	A	H448 C516 H521	H421 C489 H494
BS05	ZN	A	H253 H521	H226 H494
BS06	ZN	A	D366 H477	D339 H450
BS07	ZN	A	H328 D334	H301 D307
BS08	ZN	A	D414 D416	D387 D389

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005575 cellular_component

External links

• PDB: RCSB:5lww, PDBe:5lww, PDBj:5lww
• PDBsum: 5lww
• UniProt: A2QS62