Structure of PDB 5lwm Chain A

Receptor sequence
>5lwmA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPD
QQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDF
LQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEAHV
KIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSF
GVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAP
PACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
3D structure
PDB5lwm Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) A136 A138 R140 N141 D154
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 79T A L828 V836 A853 Y904 L905 C909 R911 D912 R953 L956 L15 V23 A40 Y91 L92 C96 R98 D99 R140 L143 MOAD: Kd=0.00134uM
PDBbind-CN: -logKd/Ki=8.87,Kd=1.34nM
BindingDB: EC50=237nM,IC50=0.130000nM
BS02 PHU A W1011 M1037 R1059 L1060 W1078 W198 M224 R246 L247 W265
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5lwm, PDBe:5lwm, PDBj:5lwm
PDBsum5lwm
PubMed27840070
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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