Structure of PDB 5lwe Chain A

Receptor sequence
>5lweA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
RQFASHFLPPLYWLVFIVGALGNSLVILVYWYCARAKTATDMFLLNLAIA
DLLFLVTLPFWAIATFMCKVVNSMYKMNFYSCVLLIMCICVDRYIAIAQA
MRAHTWREKRLLYSKMVCFTIWVLAAALCIPEILYCTTKLKSAVLALKVI
LGFFLPFVVMACCYTIIIHTLIQAKKSSKHKALKATITVLTVFVLSQFPY
NCILLVQTIDAYAMFISNCAVSTAIDICFQVTQAIAFFHSCLNPVLYVFV
GERFRRDLVKTLKNLGAISQAAAHH
3D structure
PDB5lwe Intracellular allosteric antagonism of the CCR9 receptor.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 79K A V69 Y73 R78 T81 T83 D84 L87 I140 R144 A255 T256 V259 Y317 G321 E322 R323 F324 V26 Y30 R35 T38 T40 D41 L44 I89 R93 A185 T186 V189 Y247 G251 E252 R253 F254 PDBbind-CN: -logKd/Ki=9.96,Kd=0.11nM
BindingDB: IC50=2.8nM,Ki=3.7nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016493 C-C chemokine receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lwe, PDBe:5lwe, PDBj:5lwe
PDBsum5lwe
PubMed27926729
UniProtP51686|CCR9_HUMAN C-C chemokine receptor type 9 (Gene Name=CCR9)

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