Structure of PDB 5lvv Chain A

Receptor sequence
>5lvvA (length=720) Species: 9606 (Homo sapiens) [Search protein sequence]
HHVPYSSAQSTSKTSVTLSLGGGTHADSLNNLANIKREQGNIEEAVRLYR
KALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM
GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIAS
YRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNR
LPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKL
SDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNF
RVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELF
ALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPH
TFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDV
KIVKNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAA
TGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRV
PNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLA
DVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLEL
IAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELER
LYLQMWEHYAAGNKPDHMIK
3D structure
PDB5lvv Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats.
ChainA
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A Y296 S297 Q839 K842 V895 A896 K898 H901 H920 T921 T922 D925 Y5 S6 Q531 K534 V587 A588 K590 H593 H612 T613 T614 D617 BindingDB: IC50=1800nM
External links
PDB RCSB:5lvv, PDBe:5lvv, PDBj:5lvv
PDBsum5lvv
PubMed28659383
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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