Structure of PDB 5luz Chain A

Receptor sequence
>5luzA (length=662) Species: 9606 (Homo sapiens) [Search protein sequence]
SSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYEN
CLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMS
MRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNE
IKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDFIDSLEKTDDDK
YKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLRT
KVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFIL
NLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEV
VTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLD
LYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPGRPSLLRHD
EVRTYFHQFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVD
SLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHT
NTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSE
VFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREP
NQKAFLMSRGLH
3D structure
PDB5luz Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.16: neurolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D84 A426 A427 C428 F429 Y606 Y613 D70 A411 A412 C413 F414 Y589 Y596
BS02 peptide A Y339 R554 Q555 H601 Y610 Y613 Y324 R537 Q538 H584 Y593 Y596
BS03 ZN A H474 H478 E503 H457 H461 E486
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
Biological Process
GO:0006111 regulation of gluconeogenesis
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:1902809 regulation of skeletal muscle fiber differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5luz, PDBe:5luz, PDBj:5luz
PDBsum5luz
PubMed29183787
UniProtQ9BYT8|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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