Structure of PDB 5luu Chain A

Receptor sequence
>5luuA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5luu Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.
ChainA
Resolution1.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 77X A W81 P82 L92 L94 N140 I146 W40 P41 L51 L53 N99 I105 MOAD: Kd=8.63uM
PDBbind-CN: -logKd/Ki=5.06,Kd=8.63uM
BindingDB: Kd=31300nM
External links
PDB RCSB:5luu, PDBe:5luu, PDBj:5luu
PDBsum5luu
PubMed27994766
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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