Structure of PDB 5lu8 Chain A

Receptor sequence
>5lu8A (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
GGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIA
YSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVK
GIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYK
HKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKR
STYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTQTSHVMQYGNKTI
STMKVMQFQGMKR
3D structure
PDB5lu8 Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.34: legumain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G26 R44 H45 X147 H148 C189 S216 Y217 A218 Y228 D231 W232 G1 R19 H20 X122 H123 C164 S191 Y192 A193 Y203 D206 W207
BS02 5KN A H252 H256 K259 K273 H227 H231 K234 K248
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5lu8, PDBe:5lu8, PDBj:5lu8
PDBsum5lu8
PubMed28345579
UniProtQ99538|LGMN_HUMAN Legumain (Gene Name=LGMN)

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