Structure of PDB 5lt6 Chain A

Receptor sequence
>5lt6A (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
GPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERMQCECTPLSK
DERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVIL
TEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLV
PSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLG
3D structure
PDB5lt6 Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y1579 Y1666
Catalytic site (residue number reindexed from 1) Y123 Y210
Enzyme Commision number 2.1.1.-
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1631 C1678 C1680 C1685 C175 C222 C224 C229
BS02 ZN A C1516 C1529 C1539 C60 C73 C83
BS03 ZN A C1499 C1501 C1516 C1520 C43 C45 C60 C64
BS04 76J A K1560 G1561 W1562 Y1579 Y1605 R1625 N1628 H1629 F1664 Y1666 Q1676 C1678 F1679 L1689 K104 G105 W106 Y123 Y149 R169 N172 H173 F208 Y210 Q220 C222 F223 L233 PDBbind-CN: -logKd/Ki=5.41,IC50=3.9uM
Gene Ontology
Molecular Function
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0046975 histone H3K36 methyltransferase activity
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5lt6, PDBe:5lt6, PDBj:5lt6
PDBsum5lt6
PubMed27571355
UniProtQ9BYW2|SETD2_HUMAN Histone-lysine N-methyltransferase SETD2 (Gene Name=SETD2)

[Back to BioLiP]