Structure of PDB 5lsx Chain A

Receptor sequence
>5lsxA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
GPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTEMQCECTPLSKD
ERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILT
EKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFM
ALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVP
SGSELTFDYQFQREAQKCFCGSANCRGYLGG
3D structure
PDB5lsx Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y1579 Y1666
Catalytic site (residue number reindexed from 1) Y122 Y209
Enzyme Commision number 2.1.1.-
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1631 C1678 C1680 C1685 C174 C218 C220 C225
BS02 ZN A C1501 C1516 C1520 C44 C59 C63
BS03 ZN A C1516 C1529 C1539 C59 C72 C82
BS04 76O A K1560 G1561 W1562 Y1579 H1603 Y1604 Y1605 R1625 M1627 N1628 H1629 F1664 Y1666 Q1676 C1678 F1679 K103 G104 W105 Y122 H146 Y147 Y148 R168 M170 N171 H172 F207 Y209 Q216 C218 F219 PDBbind-CN: -logKd/Ki=5.92,IC50=1.2uM
Gene Ontology
Molecular Function
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0046975 histone H3K36 methyltransferase activity
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5lsx, PDBe:5lsx, PDBj:5lsx
PDBsum5lsx
PubMed27571355
UniProtQ9BYW2|SETD2_HUMAN Histone-lysine N-methyltransferase SETD2 (Gene Name=SETD2)

[Back to BioLiP]