Structure of PDB 5lsw Chain A

Receptor sequence
>5lswA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
GPHMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGT
IAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLA
AHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTE
IIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMI
LGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTF
AQVLKDDTTTKRWLAQLVKNLQE
3D structure
PDB5lsw A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H85 N88 Q98 R130 Y134 L137 G141 K148 L177 F184 R227 H231 H73 N76 Q86 R118 Y122 L125 G129 K136 L165 F172 R215 H219
BS02 peptide A R274 Q278 R262 Q266
Gene Ontology
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0030014 CCR4-NOT complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5lsw, PDBe:5lsw, PDBj:5lsw
PDBsum5lsw
PubMed28165457
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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