Structure of PDB 5lsu Chain A

Receptor sequence
>5lsuA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLRELRETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTD
ENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTLQ
RGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI
DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG
TELTFNYNLDCLGNEKTVCRCGASNCSGFLG
3D structure
PDB5lsu Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ChainA
Resolution2.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y1092 Y1179
Catalytic site (residue number reindexed from 1) Y120 Y207
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1144 C1191 C1193 C1198 C172 C219 C221 C226
BS02 ZN A C1016 C1018 C1026 C1032 C44 C46 C54 C60
BS03 ZN A C1026 C1041 C1046 C1052 C54 C69 C74 C80
BS04 SAM A R1073 W1075 T1115 H1116 F1117 Y1118 R1138 F1139 N1141 H1142 Y1179 L1202 R101 W103 T143 H144 F145 Y146 R166 F167 N169 H170 Y207 L230
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:5lsu, PDBe:5lsu, PDBj:5lsu
PDBsum5lsu
PubMed27571355
UniProtO96028|NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (Gene Name=NSD2)

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