Structure of PDB 5lrq Chain A

Receptor sequence
>5lrqA (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKAQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINE
3D structure
PDB5lrq Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38 alpha and BRD4.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4WG A W81 P82 Q85 L94 N140 I146 W40 P41 Q44 L53 N99 I105 BindingDB: Kd=1600nM
External links
PDB RCSB:5lrq, PDBe:5lrq, PDBj:5lrq
PDBsum5lrq
PubMed31212132
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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