Structure of PDB 5lpm Chain A

Receptor sequence
>5lpmA (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
SMIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKS
PMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKL
SEVFEQEIDPVMQSLG
3D structure
PDB5lpm Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 71Y A P1074 V1079 D1080 L1084 Y1089 Y1131 N1132 P29 V34 D35 L39 Y44 Y86 N87 MOAD: Kd=2.77uM
PDBbind-CN: -logKd/Ki=5.56,Kd=2.77uM
BS02 71Y A L1083 L1084 L38 L39 MOAD: Kd=2.77uM
PDBbind-CN: -logKd/Ki=5.56,Kd=2.77uM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5lpm, PDBe:5lpm, PDBj:5lpm
PDBsum5lpm
PubMed28766825
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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