Structure of PDB 5lpg Chain A

Receptor sequence

>5lpgA (length=156) Species: 9606 (Homo sapiens)

GRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEE
CAQRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSE
PKNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVG
YKGNHL

3D structure

• PDB: 5lpg NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Enzyme Commision number: 3.6.1.9: nucleotide diphosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	E63 E67	E55 E59
BS02	71V	A	Q44 L45 G47 G48 H49 Y90 F135 G137 L138	Q36 L37 G39 G40 H41 Y82 F127 G129 L130

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
• GO:0016787 hydrolase activity
• GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
• GO:0044715 8-oxo-dGDP phosphatase activity
• GO:0046872 metal ion binding
• GO:0047429 nucleoside triphosphate diphosphatase activity

Biological Process

• GO:0000278 mitotic cell cycle
• GO:0000302 response to reactive oxygen species
• GO:0006195 purine nucleotide catabolic process
• GO:0006203 dGTP catabolic process
• GO:0009217 purine deoxyribonucleoside triphosphate catabolic process
• GO:0042178 xenobiotic catabolic process
• GO:0042262 DNA protection
• GO:0055086 nucleobase-containing small molecule metabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:1901292 nucleoside phosphate catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5lpg, PDBe:5lpg, PDBj:5lpg
• PDBsum: 5lpg
• PubMed: 27530327
• UniProt: Q9NV35|NUD15_HUMAN Nucleotide triphosphate diphosphatase NUDT15 (Gene Name=NUDT15)