Structure of PDB 5lpe Chain A

Receptor sequence
>5lpeA (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
PCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDQG
EQLRRTTRSVVHPKYRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPG
DQCQVAGWGTTANKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQ
DPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKV
IRSN
3D structure
PDB5lpe Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 S193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H36 D71 Q154 S155 D156 S157 G158
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H57 D99 D102 H36 D68 D71
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lpe, PDBe:5lpe, PDBj:5lpe
PDBsum5lpe
PubMed27611765
UniProtO43240|KLK10_HUMAN Kallikrein-10 (Gene Name=KLK10)

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