Structure of PDB 5lop Chain A

Receptor sequence
>5lopA (length=259) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence]
SLPLLRPFETVSLENAVEDLVVRFILNVPPEDLSTVERVLFHFEEASWFY
TDFVKLMNPYLPNLSIKSFSKIVIDICPLIWNWDITPENALVKFSNYKKT
IPVRGAAIFNDSLSKILLLRGINSKHWSFPRGKIGKDEDDVACCIREVKE
ETGFDLTGFIDADQYVERNMNGKNFKIFLVKGVPEDFEFKPEHKNEIQAI
EWKDFKKLSKAITKNEGFLVNSMIRPLSLYVKNEKRAKDENKLKLYAEEH
LKSILGLNK
3D structure
PDB5lop Structure of the active form of Dcp1-Dcp2 decapping enzyme bound to m(7)GDP and its Edc3 activator.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A R132 E152 R131 E151
BS02 MG A E148 E152 E197 E147 E151 E196
BS03 M7G A W49 D53 G133 K134 E148 H194 K195 N196 E197 W48 D52 G132 K133 E147 H193 K194 N195 E196
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5lop, PDBe:5lop, PDBj:5lop
PDBsum5lop
PubMed27694841
UniProtQ6CIU1

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