Structure of PDB 5lm8 Chain A

Receptor sequence

>5lm8A (length=549) Species: 5061 (Aspergillus niger)

NTPWQGYDINTNYYETIPQTNVVREYWFDIVNTTAALDGVERPVLLVNGQ
FPGPTIEANWGDTVKVHVTNRMENNGTAIHFHGIRQLYNNQMDGVAALTQ
CPVPPNSSYTYVWRAEEYGSSWYHSHFSLQAWEGVFGGILIHGPSTAEYD
HDLGMVFLNDWSHQTVDEMYQSVLESQNPPHFQTGLINGSNIWVTADNQT
VGRRFQTEFVPGQRYRLRLVNAAMHTHFRFSIDNHDLTVIASDFVPIVPF
TTNNVPIGMGQRYDIIVTANQAPDNYWIRAIPQSFCSDNANSDNIKGVLH
YEGAADNSDPTSTKWDYGDDIQCLDFSLDELVPWLALDADIGGAQMAESD
VDFTPFGDVPLYLWTMGGNALNISWKDPTLQQTFEDPDKMDWKASQGVIE
AAIPNKWTVLVVQTDLPVPHPIHLHGHDFYLLAQGFGQFNPQNVTLKTHN
PPRRDTALMTAATPENGGGGYMVIGFPADNPGVWLIHCHIGFHATEGFAQ
QIVERQSEFNTFFSEDLLENTCDAWDEYAKVNPYGHQYRALAGPYESGI

3D structure

• PDB: 5lm8 Structure and function of Aspergillus niger laccase McoG
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H108 H110 H152 H154 H448 H451 H453 H515 C516 H517 I518 H521 F526
• Catalytic site (residue number reindexed from 1): H80 H82 H124 H126 H420 H423 H425 H487 C488 H489 I490 H493 F498
• Enzyme Commision number: 1.10.3.2: laccase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CU	A	H110 H152 H517	H82 H124 H489
BS02	CU	A	H154 H453 H515	H126 H425 H487
BS03	CU	A	H108 H451 H453	H80 H423 H425
BS04	CU	A	H448 C516 H521	H420 C488 H493

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005575 cellular_component

External links

• PDB: RCSB:5lm8, PDBe:5lm8, PDBj:5lm8
• PDBsum: 5lm8
• UniProt: A2QS62