Structure of PDB 5lm4 Chain A

Receptor sequence
>5lm4A (length=389) Species: 9606 (Homo sapiens) [Search protein sequence]
EDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREVKYFAFPGELL
MRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYMSTTIIAVVLG
IILVLIIEVLDCFLDLARNIFPSNLVSAAFRSYSTQEVEGMNILGLVVFS
IVFGIALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWYAPLGILFLIAGK
IVEGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPFVFIAGILQALITALG
TSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEAVAAI
FIAQDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTAVGLPTDDITL
IIAVDWLLDRFRTMVNVLGDALGAGIVEHLSRKELEKQD
3D structure
PDB5lm4 Structure and allosteric inhibition of excitatory amino acid transporter 1.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP A S344 S345 M379 T382 G422 I423 G427 D456 R459 T460 S253 S254 M288 T291 G325 I326 G330 D359 R362 T363
BS02 6Z6 A S116 G117 G120 A123 V124 Y127 I231 I235 F369 V373 I377 S78 G79 G82 A85 V86 Y89 I151 I155 F278 V282 I286 PDBbind-CN: -logKd/Ki=3.88,Kd>131uM
Gene Ontology
Molecular Function
GO:0015293 symporter activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:5lm4, PDBe:5lm4, PDBj:5lm4
PDBsum5lm4
PubMed28424515
UniProtP43003;
Q15758|AAAT_HUMAN Neutral amino acid transporter B(0) (Gene Name=SLC1A5)

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