Structure of PDB 5llx Chain A

Receptor sequence

>5llxA (length=667) Species: 1036674 (Idiomarina sp. A28L)

ISKLIAACDQEPIHIPNAIQPFGAMLIVEKDTQQIVYASANSAEYFSVAD
NTIHELSDIKQANINSLLPEHLISGLASAIRENEPIWVETDRLSFLGWRH
ENYYIIEVERYHVQTSNWFEIQFQRAFQKLRNCKTHNDLINTLTRLIQEI
SGYDRVMIYQFDPEWNGRVIAESVRQLFTSMLNHHFPASDIPAQARAMYS
INPIRIIPDVNAEPQPLHMIHKPQNTEAVNLSSGVLRAVSPLHMQYLRNF
GVSASTSIGIFNEDELWGIVACHHTKPRAIGRRIRRLLVRTVEFAAERLW
LIHSRNVERYMVTVQAAREQLSTTADDKHSSHEIVIEHAADWCKLFRCDG
IGYLRGEELTTYGETPDQTTINKLVEWLEENGKKSLFWHSHMLKEDAPGL
LPDGSRFAGLLAIPLKSYLLLFRVAQNEVRTWAGKPEKLSVETSTGTMLG
PRKSFEAWQDEVSGKSQPWRTAQLYAARDIARDLLIVADSMQLNLLNDQL
ADANENLEKLASFDDLTGIFNRRRMEDRLESEVKEAQRYKKQFGILLFDL
DKFKSVNDTYGHNIGDQILQNTCAAVSETLRDTDKFGRWGGEEFLIIAPQ
TGMPELMQLGERVRAAVEKMQHKDLPAVTISIGVAEFQNDTRWDHMIDRA
DKAMYRAKENGRNQVCS

3D structure

• PDB: 5llx Long-range allosteric signaling in red light-regulated diguanylyl cyclases.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.65: diguanylate cyclase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LBV	A	C17 M166 F195 S198 D199 I200 P201 A204 R214 R246 H252 S266 H282	C8 M157 F186 S189 D190 I191 P192 A195 R205 R237 H243 S257 H273
BS02	GTP	A	D564 L565 D566 K567 F568 K569 N572 D581 L584 R603 G606 E607 R677	D549 L550 D551 K552 F553 K554 N557 D566 L569 R588 G591 E592 R662
BS03	MG	A	D564 L565 E607	D549 L550 E592

Gene Ontology

Molecular Function

• GO:0005525 GTP binding
• GO:0009881 photoreceptor activity
• GO:0046872 metal ion binding
• GO:0052621 diguanylate cyclase activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0009584 detection of visible light
• GO:0043709 cell adhesion involved in single-species biofilm formation
• GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:5llx, PDBe:5llx, PDBj:5llx
• PDBsum: 5llx
• PubMed: 28275738
• UniProt: F7RW09