Structure of PDB 5llm Chain A

Receptor sequence
>5llmA (length=399) Species: 9606 (Homo sapiens) [Search protein sequence]
TKEDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREVKYFAFPGE
LLMRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYMSTTIIAVV
LGIILVLIIHPEVLDCFLDLARNIFPSNLVSAAFRSYSTTPVGQEVEGMN
ILGLVVFSMVFGFALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWYAPLG
ILFLIAGKIVEGGQLGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPFVFI
AGILQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINM
DGTALYEAVAAIFIAQQIITISITATAASIGAAGIPQAGLVTMVIVLTAV
GLPTDDITLIIAVDWLLDRFRTMVNVLGDALGAGIVEHLSRKELEKQDA
3D structure
PDB5llm Structure and allosteric inhibition of excitatory amino acid transporter 1.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP A S344 S345 T382 G422 I423 A426 G427 D456 R459 T460 N463 S265 S266 T303 G334 I335 A338 G339 D368 R371 T372 N375
BS02 6Z6 A S116 G117 G120 Y127 M231 F235 F369 V373 I377 S80 G81 G84 Y91 M159 F163 F290 V294 I298 PDBbind-CN: -logKd/Ki=5.35,IC50=4.5uM
Gene Ontology
Molecular Function
GO:0015293 symporter activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:5llm, PDBe:5llm, PDBj:5llm
PDBsum5llm
PubMed28424515
UniProtP43003;
Q15758|AAAT_HUMAN Neutral amino acid transporter B(0) (Gene Name=SLC1A5)

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