Structure of PDB 5lkt Chain A

Receptor sequence

>5lktA (length=551) Species: 9606 (Homo sapiens)

KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKS
PMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKL
SEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYCTIPRDATYYSYQNRYH
FCEKCFNEIQGESVSLGQTTINKEQFSKRKNDTLDPELFVECTECGRKMH
QICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENR
VNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPY
RTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFR
PKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQ
KIPKPKRLQEWFKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFE
GDFWPNVLEESIKESGGSGSQKLYATMEKHKEVFFVIRLIAGPAANSLPP
IVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQ
S

3D structure

• PDB: 5lkt Structure of p300 in complex with acyl-CoA variants.
• Chain: A
• Resolution: 2.04 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C1177 C1183 C1201 C1204	C132 C134 C152 C155
BS02	ZN	A	C1247 C1250 C1272 C1275	C192 C195 C217 C220
BS03	ZN	A	C1163 C1164 H1255 C1258	C118 C119 H200 C203
BS04	ZN	A	H1315 C1408	H260 C353
BS05	BCO	A	S1396 Y1397 L1398 D1399 S1400 R1410 T1411 Y1414 W1436 C1438 P1440 Y1446 K1456 I1457 P1458 R1462 L1463 W1466 F1467	S341 Y342 L343 D344 S345 R355 T356 Y359 W381 C383 P385 Y391 K401 I402 P403 R407 L408 W411 F412

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:5lkt, PDBe:5lkt, PDBj:5lkt
• PDBsum: 5lkt
• PubMed: 27820805
• UniProt: Q09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)