Structure of PDB 5lj7 Chain A

Receptor sequence

>5lj7A (length=592) Species: 714 (Aggregatibacter actinomycetemcomitans)

MNIIEIKQLNRYFGEGENRVHVLKDISLSIERGDFVAIMGQSGSGKSTLM
NIIGCLDTATGGSSKIDGKETIELTNDQLSDLRSQKFGFIFQRYNLLSSL
TAAENVALPAIYAGMPQSQRLERAKQLLEKLGLGDKWQNKPNQLSGGQQQ
RVSIARALMNGGEIILADQPTGALDSHSGENVMEILRQLHEEGHTIIMVT
HDKHIAASANRIIEIKDGEIISDTQKRQVKSAVKNPSVFSKDQLMEAFRM
SVSAIVAHKMRSLLTMLGIIIGITSVVSVVALGNGSQQKILENIRGIGTN
TMTIFQNLKISDANTLSKQSYIQSVTPNTANLYGIGEQYFDVEGLKLKQG
RLLTEDDVDQSNQVVVLDESAKKAIFVIFNKRPFRVIGVVSDQSLNLYSP
YSTVLNKITGGSRIGSITVKISDDVNSTVAEKSLTELLKSLHGKKDFFIM
NSDTIKQTIENTTGTMKLLISSIAFISLIVGGIGVMNIMLVSVTERTKEI
GVRMAIGARQINILQQFLIEAVLICLIGGVAGILLSVLIGVLFNSFITDF
SMDFSTASIVTAVLFSTLIGVLFGYMPAKKAAELNPITALAQ

3D structure

• PDB: 5lj7 Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily.
• Chain: A
• Resolution: 3.25 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	V22 S42 G43 G45 K46 S47 T48 Q92	V22 S42 G43 G45 K46 S47 T48 Q92
BS02	MG	A	S47 Q92	S47 Q92
BS03	ATP	A	K136 Q143 S145 G147 Q148	K136 Q143 S145 G147 Q148

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0022857 transmembrane transporter activity

Biological Process

• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5lj7, PDBe:5lj7, PDBj:5lj7
• PDBsum: 5lj7
• PubMed: 29109272
• UniProt: Q2EHL8|MACB_AGGAC Macrolide export ATP-binding/permease protein MacB (Gene Name=macB)