Structure of PDB 5lhu Chain A

Receptor sequence
>5lhuA (length=284) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRP
KDIAIYVGSGELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGR
NWTTADLAGMRIATAYPNLVRKDLATKGIEATVIRLDGAVEISVQLGVAD
AIADVVGSGRTLSQHDLVAFGEPLCDSEAVLIERAGTDGQDQTEARDQLV
ARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIAPLADPDWVAI
RALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
3D structure
PDB5lhu Uncoupling conformational states from activity in an allosteric enzyme.
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.17: ATP phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HIS A Y217 D218 L275 Y217 D218 L275 PDBbind-CN: -logKd/Ki=4.66,IC50=22uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003879 ATP phosphoribosyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lhu, PDBe:5lhu, PDBj:5lhu
PDBsum5lhu
PubMed28781362
UniProtP9WMN1|HIS1_MYCTU ATP phosphoribosyltransferase (Gene Name=hisG)

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