Structure of PDB 5lhq Chain A

Receptor sequence
>5lhqA (length=247) Species: 10090 (Mus musculus) [Search protein sequence]
IVGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASAAHCFI
QLPKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIA
LLKIRTSTGQCAQPSRSIQTIALPPRFTDAPFGSDCEITGFGKESESDYL
YPKNLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSG
GPLICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIG
3D structure
PDB5lhq Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H47 D98 K196 G197 D198 S199 G200
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0GJ A H57 Y99 D189 S190 C191 K192 S195 S214 W215 G216 G218 H47 Y95 D193 S194 C195 K196 S199 S218 W219 G220 G222
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5lhq, PDBe:5lhq, PDBj:5lhq
PDBsum5lhq
PubMed28611361
UniProtP06869|UROK_MOUSE Urokinase-type plasminogen activator (Gene Name=Plau)

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