Structure of PDB 5lgw Chain A

Receptor sequence

>5lgwA (length=648) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]

PTVVGRIPVLDVRPVVQRGRRPAKAVTGESFEVSATVFREGHDAVGANVV
LRDPRGRPGPWTPMRELAPGTDRWGATVTAGETGTWSYTVEAWGDPVTTW
RHHARIKIPAGLDTDLVLEEGARLYERAAADVPGREDRRELLAAVDALRD
ESRPAASRLAAALTPQVDAVLARHPLRDLVTSSDPLPLLVERERALYGAW
YEFFPRSEGTPHTPHGTFRTAARRLPAIAAMGFDVVYLPPIHPIGTTHRK
GRNNTLSATGDDVGVPWAIGSPEGGHDSIHPALGTLDDFDHFVTEAGKLG
LEIALDFALQCSPDHPWVHKHPEWFHHRPDGTIAHAENPPKKYQDIYPIA
FDADPDGLATETVRILRHWMDHGVRIFRVANPHTKPVAFWERVIADINGT
DPDVIFLAEAFTRPAMMATLAQIGFQQSYTYFTWRNTKQELTEYLTELSG
EAASYMRPNFFANTPDILHAYLQHGGRPAFEVRAVLAATLSPTWGIYSGY
ELCENTPLREGSEEYLDSEKYQLKPRDWTRAAREGTTIAPLVTRLNTIRR
ENPALRQLRDLHFHPTDKEEVIAYSKRQGSNTVLVVVNLDPRHTQEATVS
LDMPQLGLDWHESVPVRDELTGETYHWGRANYVRLEPGRTPAHVCTVL

3D structure

PDB

5lgw Ligand-bound structures and site-directed mutagenesis identify the acceptor and secondary binding sites of Streptomyces coelicolor maltosyltransferase GlgE.

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.99.16: starch synthase (maltosyl-transferring).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	T426 P428 Y445	T412 P414 Y431
BS02	GLC	A	F425 Y445 W448 R449	F411 Y431 W434 R435
BS03	GLC	A	D581 K582 E610 T612 Y646	D567 K568 E596 T598 Y632
BS04	GLC	A	Y639 W641 Y646 V647 R648 H657	Y625 W627 Y632 V633 R634 H643
BS05	BGC	A	Y357 R392 N395 E423 D480	Y343 R378 N381 E409 D466
BS06	GLC	A	K264 V279 W281 Y357 D359 K534 Y535	K250 V265 W267 Y343 D345 K520 Y521

Gene Ontology

	Molecular Function
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004556	alpha-amylase activity
GO:0016757	glycosyltransferase activity
GO:0016758	hexosyltransferase activity

	Biological Process
GO:0005975	carbohydrate metabolic process
GO:0009313	oligosaccharide catabolic process
GO:0030979	alpha-glucan biosynthetic process

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5lgw, PDBe:5lgw, PDBj:5lgw
PDBsum	5lgw
PubMed	27531751
UniProt	Q9L1K2\|GLGE1_STRCO Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1 (Gene Name=glgE1)

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