Structure of PDB 5lgb Chain A

Receptor sequence
>5lgbA (length=456) Species: 10090 (Mus musculus) [Search protein sequence]
GPRVLVVGSGIAGLGAAQKLCSAAPHLRVLEATASAGGRIRSERCFGGVV
ELGAHWIHGPSQDNPVFQLAAEFGLLGEKIWSSSGTSVSLELMTEMARLF
YGLIERTREFLNESETPMASVGEFLKKEISQQVASWTDTRKRKLAILNTF
FNIECCVSGTHSMDLVALAPFGEYTVLDCILAGGYQGLTDRILASLPKDT
VAFDKPVKTIHWNGSFQEAAFPGETFPVLVECEDGARLPAHHVIVTVPLG
FLKEHQDTFFEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWQFIQVVWE
DTSPLQDTALSLQDTWFKKLIGFLVQPHVLCGFIAGLESEFMETLSDEEV
LLSLTQVLRRVTGNPQLPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDL
DLMAQPLPGLQVLFAGEATHRTFYSTTHGALLSGWREADRLVSLWDSQVE
QSRPRL
3D structure
PDB5lgb The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H64
Catalytic site (residue number reindexed from 1) H58
Enzyme Commision number 1.5.3.13: N(1)-acetylpolyamine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6YU A V11 G12 G14 A16 E37 A38 G44 R45 G59 A60 H61 W62 H64 D211 V240 V280 P281 W420 Y425 Y430 G464 E465 S473 T474 T475 A478 V7 G8 G10 A12 E31 A32 G38 R39 G53 A54 H55 W56 H58 D178 V207 V247 P248 W378 Y383 Y388 G416 E417 S425 T426 T427 A430
BS02 MD2 A V187 F201 Y204 Y430 S473 V157 F171 Y174 Y388 S425 BindingDB: Ki=1700nM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:5lgb, PDBe:5lgb, PDBj:5lgb
PDBsum5lgb
PubMed28029774
UniProtQ8C0L6|PAOX_MOUSE Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (Gene Name=Paox)

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