Structure of PDB 5lcz Chain A

Receptor sequence
>5lczA (length=195) Species: 9606,10116 [Search protein sequence]
AEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLM
FQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDMKERALIDMYSEGILD
LTEMITALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHLLELLL
YVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKPAMDA
3D structure
PDB5lcz Directed evolution of glutathione transferases towards a selective glutathione-binding site and improved oxidative stability.
ChainA
Resolution2.325 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y9 R15 R20
Catalytic site (residue number reindexed from 1) Y8 R14 R19
Enzyme Commision number 1.11.1.-
2.5.1.18: glutathione transferase.
5.3.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A Y9 R15 Q54 V55 Q67 T68 Y8 R14 Q53 V54 Q66 T67
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity

View graph for
Molecular Function
External links
PDB RCSB:5lcz, PDBe:5lcz, PDBj:5lcz
PDBsum5lcz
PubMed27612661
UniProtP04903;
P08263|GSTA1_HUMAN Glutathione S-transferase A1 (Gene Name=GSTA1)

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