Structure of PDB 5lc0 Chain A

Receptor sequence
>5lc0A (length=193) Species: 64320 (Zika virus) [Search protein sequence]
MVDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVKGETTDGVYR
VMTRGLLGSTQVGVGVMQEGVFHTMWHVTKGSALRSGEGRLDPYWGDVKQ
DLVSYCGPWKLDAAWDGHSEVQLLAVPPGERARNIQTLPGIFKTKDGDIG
AVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQ
3D structure
PDB5lc0 Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6T8 A S81 G82 D83 H1051 D1129 Y1130 A1132 G1133 S1135 G1151 N1152 G1153 V1154 V1155 Y1161 S34 G35 D36 H77 D155 Y156 A158 G159 S161 G177 N178 G179 V180 V181 Y187 PDBbind-CN: -logKd/Ki=6.70,IC50=0.20uM
BS02 6T8 A H1051 K1054 H77 K80 PDBbind-CN: -logKd/Ki=6.70,IC50=0.20uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:5lc0, PDBe:5lc0, PDBj:5lc0
PDBsum5lc0
PubMed27386922
UniProtA0A140DLX4

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