Structure of PDB 5law Chain A

Receptor sequence
>5lawA (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLY
DEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB5law Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6SJ A L54 L57 I61 M62 Y67 F86 V93 K94 H96 I99 L37 L40 I44 M45 Y50 F69 V76 K77 H79 I82 PDBbind-CN: -logKd/Ki=7.10,IC50=80nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5law, PDBe:5law, PDBj:5law
PDBsum5law
PubMed27775892
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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