Structure of PDB 5la2 Chain A

Receptor sequence

>5la2A (length=464) Species: 1515 (Acetivibrio thermocellus)

SPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGF
NAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNG
ANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANP
PGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKA
VFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTSYAGGLDV
ELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYG
NWPAARGVYGNGGLARETAGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQY
RPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGI
SGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINAL
SGGFNLNWIELSPI

3D structure

• PDB: 5la2 The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans.
• Chain: A
• Resolution: 1.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	XYS	A	N139 N170 E171 Y255 S279 F310	N103 N134 E135 Y219 S243 F266
BS02	XYP	A	W69 G136 A137	W33 G100 A101
BS03	AHR	A	E68 W69 Y92 N135 G136 N139 F310	E32 W33 Y56 N99 G100 N103 F266
BS04	ARB	A	E411 W424 F478 N507	E359 W372 F426 N455
BS05	CA	A	E377 E379 Y420 N509	E325 E327 Y368 N457
BS06	CA	A	D392 D394 V396 G407 D409	D340 D342 V344 G355 D357
BS07	CA	A	D392 D409 W424 E429	D340 D357 W372 E377

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
• GO:0030246 carbohydrate binding

Biological Process

• GO:0000272 polysaccharide catabolic process
• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:5la2, PDBe:5la2, PDBj:5la2
• PDBsum: 5la2
• PubMed: 27531750
• UniProt: A3DHG6