Structure of PDB 5l8a Chain A

Receptor sequence
>5l8aA (length=62) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
SEREKRVSNAVEFLLDSRVRRTPTSSKVHFLKSKGLSAEEICEAFTKVGQ
PKTLNEIKRILS
3D structure
PDB5l8a Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
ChainA
Resolution1.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6RB A N13 E16 F17 R22 V23 T26 F34 K38 N9 E12 F13 R18 V19 T22 F30 K34 MOAD: Ki=12.3uM
PDBbind-CN: -logKd/Ki=4.91,Ki=12.3uM
BS02 GLY A P27 T28 S29 P23 T24 S25
Gene Ontology
Biological Process
GO:0016560 protein import into peroxisome matrix, docking
Cellular Component
GO:0005778 peroxisomal membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:5l8a, PDBe:5l8a, PDBj:5l8a
PDBsum5l8a
PubMed28360328
UniProtQ8IEW2

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