Structure of PDB 5l7i Chain A

Receptor sequence
>5l7iA (length=564) Species: 562,9606 [Search protein sequence]
PPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKL
VLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAI
VERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSW
YEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADW
RNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEP
TSNETLSCVIIFVIVYYALMAGFVWFVVLTYAWHTSFLSGKTSYFHLLTW
SLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVG
GYFLIRGVMTLFSARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTK
MRAAALDAQKKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTR
NAYIQKYLERARSTLSKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQ
AEWERSFRDYVLCQANVTDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVW
TKATLLIWRRTWCR
3D structure
PDB5l7i Structural basis of Smoothened regulation by its extracellular domains.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VIS A W281 D384 S387 Y394 Q477 E518 W225 D319 S322 Y329 Q500 E531
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5l7i, PDBe:5l7i, PDBj:5l7i
PDBsum5l7i
PubMed27437577
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q99835|SMO_HUMAN Protein smoothened (Gene Name=SMO)

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